Modulation of Tight Junction Structure and Function by Kinases and Phosphatases Targeting Occludin

Abstract

Tight junctions (TJs) typically represent the most apical contacts in epithelial and endothelial cell layers where they play an essential role in the separation of extracellular or luminal spaces from underlying tissues in the body. Depending on the protein composition, TJs define the barrier characteristics and in addition maintain cell polarity. Two major… (More)
DOI: 10.1155/2012/807356

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