Modulation of Th1- and Th2-like cytokine production from mitogen-stimulated human peripheral blood mononuclear cells by phosphodiesterase inhibitors.

@article{Yoshimura1998ModulationOT,
  title={Modulation of Th1- and Th2-like cytokine production from mitogen-stimulated human peripheral blood mononuclear cells by phosphodiesterase inhibitors.},
  author={Tomoaki Yoshimura and Takuya Nagao and Toshiya Nakao and S. Watanabe and Eiseki Usami and Joji Kobayashi and Futoshi Yamazaki and H. Tanaka and Naoki Inagaki and Hiroichi Nagai},
  journal={General pharmacology},
  year={1998},
  volume={30 2},
  pages={
          175-80
        }
}
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28 Citations
Background Citations
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28 Citations

Modulation of Th1/Th2 cytokine production by selective and nonselective phosphodiesterase inhibitors administered to mice.
Suppression of anti-CD3-induced interleukin-4 and interleukin-5 release from splenocytes of Mesocestoides corti-infected BALB/c mice by phosphodiesterase 4 inhibitors.
Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells
TLDR
PGI2 analogs have an immune‐suppressive effect on previously activated and differentiated CD4 T cells in vitro and suggest that PGI2 may have a similar function in vivo.
Theophylline Suppresses IL-5 and IL-13 Production, and Lymphocyte Proliferation upon Stimulation with House Dust Mite in Asthmatic Children
TLDR
Theophylline suppresses the proliferation of lymphocytes and the production of proinflammatory Th2 cytokines, IL-5 and IL-13 induced by stimulation of PBMCs with HDM in children with BA.
Differential effect of phosphodiesterase inhibitors on IL‐13 release from peripheral blood mononuclear cells
TLDR
Results suggest that type 4 PDE inhibitors, alone or synergistically in combination with forskolin, inhibit PHA‐induced IL‐13 release from PBMC of atopic asthma patients by elevating intracellular cAMP concentrations.
Effects of caffeine and phosphodiesterase inhibitors on activation of neonatal T lymphocytes.
[Originals] A specific phosphodiesterase 4 inhibitor, rolipram, downregulates mite antigen-induced expression of interleukin-5 mRNA in human peripheral blood mononuclear cells
TLDR
This study indicates that rolipram definitely downregulates mite antigen-induced activation of peripheral immunocompetent cells, and suggests that this phenomenon is not directly dependent on PKA activation.
Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis
TLDR
Sensitive real-time PCR for quantifying cytokine mRNA in the blood CD4- cells revealed that the ibudilast monotherapy significantly reduced tumour necrosis factor-a and interferon (IFN)-g mRNA and the IFN-g/interleukin-4 mRNA ratio, suggesting a shift in the cytokine profile from Th1 toward Th2 dominancy.
Differential effect of phosphodiesterase IV inhibitor RP73401 on various inflammatory and immune responses relevent to rheumatoid arthritis.
The effects of anti-asthma drugs on the phagocytic clearance of apoptotic eosinophils by A549 cells.
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TLDR
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TLDR
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TLDR
With the exception of theophylline, there was a high degree of correlation between the potency to suppress TNF-alpha production in the cell culture system and the potencyto inhibit PDE activity in thecell-free enzymatic assay, arguing for a crucial role of PDE inhibition in the suppression of T NF-alpha synthesis by xanthine derivatives.
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