Modulation of Th1- and Th2-like cytokine production from mitogen-stimulated human peripheral blood mononuclear cells by phosphodiesterase inhibitors.

@article{Yoshimura1998ModulationOT,
  title={Modulation of Th1- and Th2-like cytokine production from mitogen-stimulated human peripheral blood mononuclear cells by phosphodiesterase inhibitors.},
  author={Tomoaki Yoshimura and Takuya Nagao and Toshiya Nakao and S. Watanabe and Eiseki Usami and Joji Kobayashi and Futoshi Yamazaki and H. Tanaka and Naoki Inagaki and Hiroichi Nagai},
  journal={General pharmacology},
  year={1998},
  volume={30 2},
  pages={
          175-80
        }
}
Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells
TLDR
PGI2 analogs have an immune‐suppressive effect on previously activated and differentiated CD4 T cells in vitro and suggest that PGI2 may have a similar function in vivo.
Theophylline Suppresses IL-5 and IL-13 Production, and Lymphocyte Proliferation upon Stimulation with House Dust Mite in Asthmatic Children
TLDR
Theophylline suppresses the proliferation of lymphocytes and the production of proinflammatory Th2 cytokines, IL-5 and IL-13 induced by stimulation of PBMCs with HDM in children with BA.
Differential effect of phosphodiesterase inhibitors on IL‐13 release from peripheral blood mononuclear cells
TLDR
Results suggest that type 4 PDE inhibitors, alone or synergistically in combination with forskolin, inhibit PHA‐induced IL‐13 release from PBMC of atopic asthma patients by elevating intracellular cAMP concentrations.
[Originals] A specific phosphodiesterase 4 inhibitor, rolipram, downregulates mite antigen-induced expression of interleukin-5 mRNA in human peripheral blood mononuclear cells
TLDR
This study indicates that rolipram definitely downregulates mite antigen-induced activation of peripheral immunocompetent cells, and suggests that this phenomenon is not directly dependent on PKA activation.
Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis
TLDR
Sensitive real-time PCR for quantifying cytokine mRNA in the blood CD4- cells revealed that the ibudilast monotherapy significantly reduced tumour necrosis factor-a and interferon (IFN)-g mRNA and the IFN-g/interleukin-4 mRNA ratio, suggesting a shift in the cytokine profile from Th1 toward Th2 dominancy.
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TLDR
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TLDR
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