Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1.

@article{Lin2004ModulationOT,
  title={Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1.},
  author={Ling Lin and Melanie S. Spoor and Andrea J. Gerth and Steven L Brody and Stanford L. Peng},
  journal={Science},
  year={2004},
  volume={303 5660},
  pages={1017-20}
}
Forkhead transcription factors play key roles in the regulation of immune responses. Here, we identify a role for one member of this family, Foxj1, in the regulation of T cell activation and autoreactivity. Foxj1 deficiency resulted in multiorgan systemic inflammation, exaggerated Th1 cytokine production, and T cell proliferation in autologous mixed lymphocyte reactions. Foxj1 suppressed NF-kappaB transcription activity in vitro, and Foxj1-deficient T cells possessed increased NF-kappaB… CONTINUE READING

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