Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kappaB.

@article{Mohan2000ModulationOT,
  title={Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kappaB.},
  author={Rahul Mohan and Wan Jong Kim and Steven E Wilson},
  journal={Investigative ophthalmology & visual science},
  year={2000},
  volume={41 6},
  pages={1327-36}
}
PURPOSE Previous studies have suggested no role for tumor necrosis factor (TNF)-alpha in the modulation of apoptosis in corneal fibroblasts. However, recent investigations have demonstrated that nuclear factor (NF)-kappaB activation by TNF-alpha mediates negative apoptotic effects that must be blocked to unmask the apoptotic effects of TNF-alpha in vitro. The purpose of this study was to investigate the role of transcription factor NF-kappaB in the suppression of TNF-alpha-induced apoptosis of… CONTINUE READING
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