Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis

@inproceedings{Dan2015ModulationOT,
  title={Modulation of TNF-α mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis},
  author={Cao Dan and Bian Jinjun and Hua Zi-Chun and Ma Lin and Chen Wei and Zhang Xu and Zhou Ri and Cheng Shun and Sun Wen-Zhu and Jiao Qing-Cai and Yin Wu},
  booktitle={EMBO molecular medicine},
  year={2015}
}
Immunoparalysis is an important pathological mechanism in sepsis. However, an effective small molecule therapy is lacking. Here, we show that ouabain, a Na(+),K(+)-ATPase ligand, can reverse immunoparalysis in vitro, in vivo, and in clinical samples. Notably, the effect of ouabain was critically dependent on TNF-α expression. However, ouabain had opposing effects on the stability of TNF-α mRNA: Ouabain triggered miR-181 transcription, which promoted TNF-α mRNA degradation and induced… CONTINUE READING
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