Modulation of T-cell function by gliomas.

  title={Modulation of T-cell function by gliomas.},
  author={Thomas L. Roszman and Lucinda H. Elliott and William H. Brooks},
  journal={Immunology today},
  volume={12 10},
Patients with primary intracranial tumors (gliomas) exhibit a profound decrease in immunity, the mechanism of which has, until recently, remained obscure. Here Thomas Roszman, Lucinda Elliott and William Brooks reveal that T cells obtained from these patients exhibit defects in interleukin 2 secretion and in expression of the high-affinity IL-2 receptor and they discuss the role played by immunosuppressive factors produced by gliomas in inducing these defects. 

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