Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB.

@article{Ayroldi2001ModulationOT,
  title={Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB.},
  author={E. Ayroldi and G. Migliorati and S. Bruscoli and C. Marchetti and O. Zollo and L. Cannarile and F. D'Adamio and C. Riccardi},
  journal={Blood},
  year={2001},
  volume={98 3},
  pages={
          743-53
        }
}
Previously a novel gene was identified that encodes a glucocorticoid-induced leucine zipper (GILZ) whose expression is up-regulated by dexamethasone. This study analyzed the role of GILZ in the control of T-cell activation and its possible interaction with nuclear factor kappaB (NF-kappaB). Results indicate that GILZ inhibits both T-cell receptor (TCR)-induced interleukin-2/interleukin-2 receptor expression and NF-kappaB activity. In particular, GILZ inhibits NF-kappaB nuclear translocation and… Expand
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