Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB.

@article{Ayroldi2001ModulationOT,
  title={Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB.},
  author={Emira Ayroldi and Graziella Migliorati and Stefano Bruscoli and Cristina Marchetti and Ornella Zollo and Lorenza Cannarile and Francesca D'Adamio and Carol Riccardi},
  journal={Blood},
  year={2001},
  volume={98 3},
  pages={
          743-53
        }
}
Previously a novel gene was identified that encodes a glucocorticoid-induced leucine zipper (GILZ) whose expression is up-regulated by dexamethasone. This study analyzed the role of GILZ in the control of T-cell activation and its possible interaction with nuclear factor kappaB (NF-kappaB). Results indicate that GILZ inhibits both T-cell receptor (TCR)-induced interleukin-2/interleukin-2 receptor expression and NF-kappaB activity. In particular, GILZ inhibits NF-kappaB nuclear translocation and… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 208 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 121 extracted citations

Recombinant long-glucocorticoid-induced leucine zipper (L-GILZ) protein restores the control of proliferation in gilz KO spermatogonia.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2014
View 4 Excerpts
Highly Influenced

209 Citations

01020'03'06'10'14'18
Citations per Year
Semantic Scholar estimates that this publication has 209 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 69 references