Modulation of Striatal Dopamine Release by Glycine Transport Inhibitors

@article{Javitt2005ModulationOS,
  title={Modulation of Striatal Dopamine Release by Glycine Transport Inhibitors},
  author={D. C. Javitt and Audrey Hashim and Henry W. Sershen},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={649-656}
}
Traditional models of schizophrenia have focused primarily upon dopaminergic (DA) dysregulation. In contrast, more recent models focus on dysfunction of glutamatergic systems, acting particularly through N-methyl-D-aspartate (NMDA) receptors. NMDA receptors in brain are regulated by glycine, acting via a strychnine-insensitive regulatory site, and by glycine (GlyT1) transporters that maintain low glycine levels in the immediate vicinity of the NMDA receptor complex. The present study… CONTINUE READING
16 Extracted Citations
74 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 16 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 74 references

Similar Papers

Loading similar papers…