Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination.

  title={Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination.},
  author={Joyce K. Hu and Colin Havenar-Daughton and Shane Crotty},
  journal={Current opinion in virology},
  volume={3 3},
Generating long-term humoral immunity is a crucial component of successful vaccines and requires interactions between T cells and B cells in germinal centers (GC). In GCs, a specialized subset of CD4+ helper T cells, called T follicular helper cells (Tfh), provide help to B cells; this help directs the magnitude and quality of the antibody response. Tfh cell help influences B cell survival, proliferation, somatic hypermutation, class switch recombination, and differentiation. Sustained contact… CONTINUE READING
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Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9

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