Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder

@article{Dodhia2014ModulationOR,
  title={Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder},
  author={Sonam Dodhia and Avinash Hosanagar and Daniel A. Fitzgerald and Izelle Labuschagne and Amanda G. Wood and Pradeep J. Nathan and K. Luan Phan},
  journal={Neuropsychopharmacology},
  year={2014},
  volume={39},
  pages={2061-2069}
}
Generalized social anxiety disorder (GSAD) is characterized by aberrant patterns of amygdala-frontal connectivity to social signals of threat and at rest. The neuropeptide oxytocin (OXT) modulates anxiety, stress, and social behaviors. Recent functional neuroimaging studies suggest that these effects are mediated through OXT’s effects on amygdala reactivity and/or amygdala-frontal connectivity. The aim of the current study was to examine OXT’s effects on amygdala-frontal resting-state… CONTINUE READING
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