Modulation of Replicative Lifespan in Cryptococcus neoformans: Implications for Virulence

  title={Modulation of Replicative Lifespan in Cryptococcus neoformans: Implications for Virulence},
  author={Tejas Bouklas and Neena S Jain and Bettina C Fries},
  booktitle={Front. Microbiol.},
The fungal pathogen, Cryptococcus neoformans, has been shown to undergo replicative aging. Old cells are characterized by advanced generational age and phenotypic changes that appear to mediate enhanced resistance to host and antifungal-based killing. As a consequence of this age-associated resilience, old cells accumulate during chronic infection. Based on these findings, we hypothesized that shifting the generational age of a pathogenic yeast population would alter its vulnerability to the… CONTINUE READING
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