Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells “LAG-3-ing” Behind

  title={Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells “LAG-3-ing” Behind},
  author={Meghan M. Delmastro and Alexis Styche and Massimo M. Trucco and Creg J Workman and Dario A. A. Vignali and Jon D Piganelli},
Preventing activation of diabetogenic T cells is critical for delaying type 1 diabetes onset. The inhibitory molecule lymphocyte activation gene 3 (LAG-3) and metalloprotease tumor necrosis factor-α converting enzyme (TACE) work together to regulate TH1 responses. The aim of this study was to determine if regulating redox using a catalytic antioxidant (CA) could modulate TACE-mediated LAG-3 shedding to impede diabetogenic T-cell activation and progression to disease. A combination of in vitro… CONTINUE READING


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Mechanisms maintaining peripheral tolerance

  • DL Mueller
  • Nat Immunol
  • 2010
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