Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells “LAG-3-ing” Behind

@inproceedings{Delmastro2012ModulationOR,
  title={Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells “LAG-3-ing” Behind},
  author={Meghan M. Delmastro and Alexis Styche and Massimo M. Trucco and Creg J Workman and Dario A. A. Vignali and Jon D Piganelli},
  booktitle={Diabetes},
  year={2012}
}
Preventing activation of diabetogenic T cells is critical for delaying type 1 diabetes onset. The inhibitory molecule lymphocyte activation gene 3 (LAG-3) and metalloprotease tumor necrosis factor-α converting enzyme (TACE) work together to regulate TH1 responses. The aim of this study was to determine if regulating redox using a catalytic antioxidant (CA) could modulate TACE-mediated LAG-3 shedding to impede diabetogenic T-cell activation and progression to disease. A combination of in vitro… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Mechanisms maintaining peripheral tolerance

  • DL Mueller
  • Nat Immunol
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…