Modulation of Prohormone Convertase 2 in Spinal Cord during Gestation and Hormone-Simulated Pregnancy

@article{Varshney1999ModulationOP,
  title={Modulation of Prohormone Convertase 2 in Spinal Cord during Gestation and Hormone-Simulated Pregnancy},
  author={Charu Varshney and Mildred Rivera and Alan R. Gintzler},
  journal={Neuroendocrinology},
  year={1999},
  volume={70},
  pages={268 - 279}
}
Gestation as well as its hormonal simulation (HSP) is characterized by an enhanced spinal dynorphin/ĸ-opioid antinociception. This antinociception is accompanied by decreased content of dynorphin precursor intermediates and increased content of mature dynorphin peptides (1–17 and 1–8) in the lumbar spinal region. This suggests that augmented processing of spinal dynorphin precursor intermediates is an adaptive mechanism used by dynorphin neurons to meet increased synthetic demands necessitated… 
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References

SHOWING 1-10 OF 61 REFERENCES
Spinal Cord Dynorphin Precursor Intermediates Decline During Late Gestation
TLDR
It is suggested that enhanced processing of Dynorphin precursor intermediates represents the initial biochemical level of adaptation of spinal dynorphin neurons to increased demands of pregnancy.
Spinal cord dynorphin: positive region-specific modulation during pregnancy and parturition
TLDR
It is concluded that some parameter(s) of the pregnant condition triggers the activation of a spinal cord dynorphin system that attenuates the pain associated with late pregnancy and labor.
17 beta-estradiol and progesterone positively modulate spinal cord dynorphin: relevance to the analgesia of pregnancy.
TLDR
It is concluded that changes in circulating 17 beta-estradiol and progesterone, that occur as a natural consequence of gestation, activate a dynorphin system in the lumbar spinal cord, which attenuates the pain associated with late pregnancy and labor.
Involvement of spinal cord δ opiate receptors in the antinociception of gestation and its hormonal simulation
TLDR
Data indicate that delta opiate receptor activity is a prerequisite for the manifestation of a substantial portion of gestational and HSP analgesia and the ability of estrogen and progesterone to modulate spinal opioid antinociceptive activity emphasizes potential differences between men and women in their response to pain medication.
Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis
TLDR
The identification of specific combinations of convertase expression together with CPE and PAM expression in neuropeptide-rich brain regions suggests that specific enzymatic pathways are involved in neuroPeptide precursor processing, and that these specific combinations are responsible for region-specific differences of posttranslational processing.
Estrogen and progesterone activate spinal kappa-opiate receptor analgesic mechanisms
TLDR
Exposure (of non-pregnant animals) to the pregnancy blood profile of E2 and P activates a spinal cord kappa-opiate receptor analgesic system, as occurs during actual gestation, which indicates that exposure to this pregnancy-associated antinociception indicates that a less robust constituent of intrinsic opioid pain-attenuating systems in the spinal cord is recruited.
Time course of enkephalin mRNA and peptides in cultured rat adrenal medulla.
TLDR
This work has used rapid and sensitive solution hybridization methods to measure preproenkephalin (PPenk) mRNA and total cellular RNA in samples from rat tissues and adrenal medullary explants to identify changes in enkephalins and catecholamines seen in vivo in response to denervation.
Gestational and ovarian sex steroid antinociception: synergy between spinal κ and δ opioid systems
TLDR
Data indicate that gestational and ovarian sex steroid-induced antinociception is not simply the sum of the independent analgesic effects of spinal κ and δ opioid systems but requires their coincident activation.
17-β-Estradiol and progesterone modulate an intrinsic opioid analgesic system
TLDR
Simulation of the pregnancy blood profile of 17-β-estradiol and progesterone in non-pregnant, ovariectomized rats resulted in a statistically significant elevation in pain thresholds, indicating that the entire pregnancy profile of steroid hormones is responsible for the manifestation of analgesia.
Differential effect of chronic morphine on mRNA encoding adenylyl cyclase isoforms: relevance to physiological sequela of tolerance/dependence.
TLDR
Results indicate that persistent activation of opiate receptors can induce selective changes in the abundance (activity) of AC isoforms, which could explain, in part, some of the adaptations that occur following chronic in vivo morphine exposure.
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