Modulation of Prohormone Convertase 2 in Spinal Cord during Gestation and Hormone-Simulated Pregnancy

  title={Modulation of Prohormone Convertase 2 in Spinal Cord during Gestation and Hormone-Simulated Pregnancy},
  author={Charu Varshney and Mildred Rivera and Alan R. Gintzler},
  pages={268 - 279}
Gestation as well as its hormonal simulation (HSP) is characterized by an enhanced spinal dynorphin/ĸ-opioid antinociception. This antinociception is accompanied by decreased content of dynorphin precursor intermediates and increased content of mature dynorphin peptides (1–17 and 1–8) in the lumbar spinal region. This suggests that augmented processing of spinal dynorphin precursor intermediates is an adaptive mechanism used by dynorphin neurons to meet increased synthetic demands necessitated… 
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