Modulation of Peripheral μ-Opioid Analgesia by σ1 Receptors

@article{SnchezFernndez2014ModulationOP,
  title={Modulation of Peripheral $\mu$-Opioid Analgesia by $\sigma$1 Receptors},
  author={Cristina S{\'a}nchez-Fern{\'a}ndez and {\'A}ngeles Montilla-Garc{\'i}a and Rafael C. Gonz{\'a}lez-Cano and Francisco Rafael Nieto and Luc{\'i}a Romero and Antonia Artacho-Cord{\'o}n and Rosa Montes and Bego{\~n}a Fern{\'a}ndez-Pastor and Manuel Merlos and Jose M. Baeyens and Jos{\'e} Manuel Entrena and Enrique J. Cobos},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2014},
  volume={348},
  pages={32 - 45}
}
We evaluated the effects of σ1-receptor inhibition on μ-opioid–induced mechanical antinociception and constipation. σ1-Knockout mice exhibited marked mechanical antinociception in response to several μ-opioid analgesics (fentanyl, oxycodone, morphine, buprenorphine, and tramadol) at systemic (subcutaneous) doses that were inactive in wild-type mice and even unmasked the antinociceptive effects of the peripheral μ-opioid agonist loperamide. Likewise, systemic (subcutaneous) or local… 
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