Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule.

@article{Ferrari2007ModulationOP,
  title={Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule.},
  author={Davide Ferrari and Cinzia Pizzirani and Sara Gulinelli and Giulia Callegari and Paola Chiozzi and Marco Idzko and Elisabeth Panther and Francesco Di Virgilio},
  journal={British journal of pharmacology},
  year={2007},
  volume={150 4},
  pages={445-54}
}
BACKGROUND AND PURPOSE P2X7 is a membrane receptor for extracellular ATP which is highly expressed in dendritic cells, macrophages and microglia where it mediates pro-inflammatory responses. The antibiotic polymyxin B, which binds to and neutralizes the toxic residue of bacterial lipopolysaccharide, greatly amplifies cellular responses mediated by the P2X7 receptor. However, the molecular mechanism involved is so far unknown. EXPERIMENTAL APPROACH We investigated the effects of polymyxin B… CONTINUE READING
Highly Cited
This paper has 21 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…