Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin.

@article{Zong2003ModulationOP,
  title={Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin.},
  author={Jian Zong and Gary M. Pollack},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={306 2},
  pages={
          556-62
        }
}
The objective of the present study was to examine the time course and concentration dependence of modulation of P-glycoprotein (P-gp) activity in the blood-brain barrier (BBB) with consequent influence on substrate uptake into brain tissue. Potential P-gp inducers (rifampin and morphine) were administered subchorionically to P-gp-competent [mdr1a(+/+)] mice to induce P-gp expression in brain; the impact of rifampin pretreatment on brain penetration of verapamil also was evaluated with an in… CONTINUE READING

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