Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet.

@article{Chung2007ModulationOP,
  title={Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet.},
  author={Soo Yeon Chung and Dae Sik Jang and Ah-Reum Han and Jung Ok Jang and Youngjoo Kwon and Eun-Kyoung Seo and Hwa Jeong Lee},
  journal={Phytotherapy research : PTR},
  year={2007},
  volume={21 6},
  pages={
          565-9
        }
}
This study examined the effects of the kaempferol derivatives extracted from Zingiber zerumbet on the accumulation and efflux of [(3)H]-daunomycin (DNM) in P-glycoprotein (P-gp) overexpressing multidrug resistant (MDR) human breast cancer cells, MCF-7/ADR. Of six kaempferol derivatives extracted from Z. zerumbet, kaempferol-3-O-methyl ether (1) and kaempferol-3,4'-O-dimethyl ether (2) showed a potent P-gp inhibitory effect as great as verapamil, a well-known P-gp inhibitor. The P-gp inhibitory… CONTINUE READING

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