Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.

@article{Anuchapreeda2002ModulationOP,
  title={Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.},
  author={Songyot Anuchapreeda and Pranee Leechanachai and Melissa M. Smith and Suresh V Ambudkar and Porn-ngarm Limtrakul},
  journal={Biochemical pharmacology},
  year={2002},
  volume={64 4},
  pages={
          573-82
        }
}
Multidrug resistance (MDR) is a phenomenon that is often associated with decreased intracellular drug accumulation in the tumor cells of a patient, resulting from enhanced drug efflux. It is often related to the overexpression of P-glycoprotein (Pgp) on the surface of tumor cells, thereby reducing drug cytotoxicity. In this study, curcumin was tested for its potential ability to modulate the expression and function of Pgp in the multidrug-resistant human cervical carcinoma cell line KB-V1… CONTINUE READING
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