Modulation of Nrf2 expression alters high glucose-induced oxidative stress and antioxidant gene expression in mouse mesangial cells.

@article{Li2011ModulationON,
  title={Modulation of Nrf2 expression alters high glucose-induced oxidative stress and antioxidant gene expression in mouse mesangial cells.},
  author={Hang Li and Fuxu Wang and Lianshan Zhang and Yanping Cao and Wei Liu and Jun Hao and Qingjuan Liu and Huijun Duan},
  journal={Cellular signalling},
  year={2011},
  volume={23 10},
  pages={1625-32}
}
Reactive oxygen species (ROS) play an important role in the pathogenesis of diabetic nephropathy. Nuclear factor erythroid 2-related factor 2 (Nrf2) can up-regulate the expression of antioxidant genes and protect cells from oxidative damage. The current study is aimed at examining the effect of modulation of Nrf2 expression on high glucose-induced oxidative stress and Nrf2-targeting antioxidant expression in mouse mesangial cells. In this study, mouse mesangial cells were transiently… CONTINUE READING