Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo.

  title={Modulation of Nrf2-dependent gene transcription by bilberry anthocyanins in vivo.},
  author={Christopher Kropat and Dolores Mueller and Ute Boettler and Kristin Zimmermann and Elke Hannelore Heiss and Verena M. Dirsch and Dorothee Rogoll and Ralph Melcher and Elke Richling and Doris Marko},
  journal={Molecular nutrition & food research},
  volume={57 3},
In a human pilot intervention study (healthy + ileostomy probands), the questions were addressed whether in vivo consumption of an anthocyanin-rich bilberry (Vaccinium myrtillius L.) pomace extract (BE) affects (i) the transcription of Nrf2-dependent genes in peripheral blood mononuclear cells (PBMC), indicative for systemic effects, and (ii) the level of oxidative DNA damage in these cells. In healthy test subjects transcripts of NAD(P)H quinone oxidoreductase 1 (NQO1) were significantly… CONTINUE READING
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