Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy

@inproceedings{Lin2010ModulationON,
  title={Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy},
  author={Chun-Liang Lin and F. S. Wang and Yen-Chen Hsu and Cheng-Nan Chen and Min-Jen Tseng and Moin Saleem and Pey-Jium Chang and Jeng-Yi Wang},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE Disturbances in podocytes are typically associated with marked proteinuria, a hallmark of diabetic nephropathy. This study was conducted to investigate modulation of Notch-1 signaling in high glucose (HG)-stressed human podocytes and in a diabetic animal model. RESEARCH DESIGN AND METHODS Expression of the Notch signaling components was examined in HG-treated podocytes, human embryonic kidney cells (HEK293), and kidneys from diabetic animals by RT-qPCR, Western blot analysis, and… CONTINUE READING
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