Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22.

@article{Chen2008ModulationON,
  title={Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22.},
  author={Tingjun Chen and Zhijing Hu and R{\'e}mi Quirion and Yanguo Hong},
  journal={Neuropharmacology},
  year={2008},
  volume={54 5},
  pages={796-803}
}
The sensory neuron-specific receptor (SNSR) is exclusively distributed in dorsal root ganglion (DRG) cells. We have demonstrated that intrathecal (i.t.) administration of SNSR agonists inhibits formalin-evoked responses and the development of morphine tolerance [Chen, T., Cai, Q., Hong, Y., 2006. Intrathecal sensory neuron-specific receptor agonists bovine adrenal medulla 8-22 and (tyr(6))-gamma2-msh-6-12 inhibit formalin-evoked nociception and neuronal fos-like immunoreactivity in the spinal… CONTINUE READING

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