Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation

@inproceedings{Leung2013ModulationON,
  title={Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation},
  author={Wai-Hang Leung and Queenie P. Vong and Wenwei Lin and Laura Janke and Taosheng Chen and Wing Leung},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Tumor metastasis and lack of NKG2D ligand (NKG2DL) expression are associated with poor prognosis in patients with colon cancer. Here, we found that spironolactone (SPIR), an FDA-approved diuretic drug with a long-term safety profile, can up-regulate NKG2DL expression in multiple colon cancer cell lines by activating the ATM-Chk2-mediated checkpoint pathway, which in turn enhances tumor elimination by natural killer cells. SPIR can also up-regulate the expression of metastasis-suppressor genes… CONTINUE READING

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Here , we found that spironolactone ( SPIR ) , an FDA - approved diuretic drug with a long - term safety profile , can up - regulate NKG2DL expression in multiple colon cancer cell lines by activating the ATM - Chk2-mediated checkpoint pathway , which in turn enhances tumor elimination by natural killer cells .
Here , we found that spironolactone ( SPIR ) , an FDA - approved diuretic drug with a long - term safety profile , can up - regulate NKG2DL expression in multiple colon cancer cell lines by activating the ATM - Chk2-mediated checkpoint pathway , which in turn enhances tumor elimination by natural killer cells .
Here , we found that spironolactone ( SPIR ) , an FDA - approved diuretic drug with a long - term safety profile , can up - regulate NKG2DL expression in multiple colon cancer cell lines by activating the ATM - Chk2-mediated checkpoint pathway , which in turn enhances tumor elimination by natural killer cells .
Nuclear Hormone ReceptorsIs chemical classification of gene productRetinoid X Receptors
By screening the human nuclear hormone receptor siRNA library , we identified retinoid X receptor γ ( RXRγ ) instead as being indispensable for the antitumor functions of SPIR .
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