Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells.

@article{Helms2007ModulationON,
  title={Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells.},
  author={Whitney S. Helms and Jerry Jeffrey and Derek A. Holmes and Michael B. Townsend and Neil A. Clipstone and Lishan Su},
  journal={Journal of leukocyte biology},
  year={2007},
  volume={82 2},
  pages={361-9}
}
We have reported previously that p115Rho guanine nucleotide exchange factor, its upstream activator Galpha13, and its effector RhoA are able to inhibit HIV-1 replication. Here, we show that RhoA is able to inhibit HIV-1 gene expression through the NFAT-binding site in the HIV long-terminal repeat. Constitutively active NFAT counteracts the inhibitory activity of RhoA, and inhibition of NFAT activation also inhibits HIV-1 gene expression. We have shown further that RhoA inhibits NFAT-dependent… CONTINUE READING

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