Modulation of N-methyl-D-aspartate receptors by donepezil in rat cortical neurons.

@article{Moriguchi2005ModulationON,
  title={Modulation of N-methyl-D-aspartate receptors by donepezil in rat cortical neurons.},
  author={Shigeki Moriguchi and Xilong Zhao and William Marszalec and Jay Z. Yeh and Toshio Narahashi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={315 1},
  pages={
          125-35
        }
}
Nicotinic acetylcholine receptors and N-methyl-D-aspartate (NMDA) receptors are known to be down-regulated in the brain of patients with Alzheimer's disease. It was previously shown that the nootropic drugs nefiracetam and galantamine potentiate the activity of both nicotinic and NMDA receptors. We hypothesized that donepezil, a nootropic with a potent anticholinesterase activity, might also affect the NMDA system. NMDA-induced currents were recorded from rat cortical neurons in primary culture… CONTINUE READING

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Donepezil modulates NMDA receptor activity (Abstract)

S Moriguchi, W Marszalec, X Zhao, JZ Yeh, T Narahashi
  • Soc Neurosci
  • 2004
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Alzheimer’s drug nefiracetam modulates the activity of NMDA receptors in rat cortical neurons (Abstract)

S Moriguchi, W Marszalec, X Zhao, JZ Yeh, T Narahashi
  • Soc Neurosci
  • 2003
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL