Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

  title={Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity},
  author={Ioannis Mitroulis and Klara Ruppova and Baomei Wang and Lan-Sun Chen and Michal Grzybek and Tatyana Grinenko and Anne Eugster and Maria Troullinaki and Alessandra Palladini and Ioannis Kourtzelis and Antonios Chatzigeorgiou and Andreas Schlitzer and Marc Beyer and Leo A B Joosten and Berend Isermann and Mathias Lesche and Andreas Petzold and Kai Simons and Ian Henry and Andreas R. Dahl and Joachim L. Schultze and Ben Wielockx and Nicola Zamboni and Peter Mirtschink and {\"U}nal Coskun and George Hajishengallis and Mihai G. Netea and Triantafyllos Chavakis},
Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1β and… CONTINUE READING
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