Modulation of Mrps12/Sarsm promoter activity in response to mitochondrial stress.

@article{Zanotto2008ModulationOM,
  title={Modulation of Mrps12/Sarsm promoter activity in response to mitochondrial stress.},
  author={Ernesto Zanotto and Veikka Lehtonen and Howard T. Jacobs},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1783 12},
  pages={2352-62}
}
Transcription from the bidirectional promoter of two mouse genes encoding components of the mitochondrial translational apparatus, mitoribosomal protein S12 (Mrps12) and mitochondrial seryl-tRNA ligase (Sarsm), was shown previously to be dependent upon an array of four CCAAT boxes, interacting with the transcription factor NF-Y. Here we report that the homologous human promoter is governed by a CCAAT box array acting in an essentially similar manner. Analysis of the transcriptional response of… CONTINUE READING