Modulation of Monoamine Transporters by Common Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in Human Embryonic Kidney 293 Cells and Brain Synaptosomes

@article{Xie2008ModulationOM,
  title={Modulation of Monoamine Transporters by Common Biogenic Amines via Trace Amine-Associated Receptor 1 and Monoamine Autoreceptors in Human Embryonic Kidney 293 Cells and Brain Synaptosomes},
  author={Zhihua Xie and Susan Westmoreland and Gregory M. Miller},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={325},
  pages={629 - 640}
}
In brain monoaminergic systems, common biogenic amines, including dopamine, norepinephrine, and serotonin, serve as neurotransmitters. Monoamine autoreceptors provide feedback regulation in neurotransmitter release, and monoamine transporters clear the released neurotransmitters to control synaptic signaling. Recently, trace amine-associated receptor 1 (TAAR1) has been found to be expressed in brain monoaminergic nuclei and activated by common biogenic amines in vitro. This study used… 
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  • Z. Xie, G. Miller
  • Biology, Chemistry
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Molecular details of TAAR1-ligand promiscuity are pointed to and specific trace amines are identified as allosteric or orthosteric ligands of particular β-adrenergic receptor subtypes are identified.
The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor
TLDR
Evidence is found for 5-HT1b as a new receptor target for 3-T1AM, albeit with a different signaling effect than the endogenous ligand, and a complex interrelation of signaling effects between the investigated GPCRs and respective ligands.
The Case for TAAR1 as a Modulator of Central Nervous System Function
TLDR
The bulk of evidence points to a significant physiological role of TAAR1 in the modulation of central nervous system function and a potential pharmacological role ofTAAR1 agonists in neurology and/or psychiatry, but many crucial issues require further investigation.
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β-Phenylethylamine Alters Monoamine Transporter Function via Trace Amine-Associated Receptor 1: Implication for Modulatory Roles of Trace Amines in Brain
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