Modulation of Meal Pattern in the Rat by the Anorexic Lipid Mediator Oleoylethanolamide

  title={Modulation of Meal Pattern in the Rat by the Anorexic Lipid Mediator Oleoylethanolamide},
  author={Silvana Gaetani and Fariba Oveisi and Daniele Piomelli},
Oleoylethanolamide (OEA) is a structural analog of the endogenous cannabinoid anandamide, which does not activate cannabinoid receptors. The biosynthesis of OEA in rat small intestine is increased by feeding and reduced by fasting. Moreover, OEA decreases food intake in food-deprived rats via a mechanism that requires intact sensory fibers (Rodríguez de Fonseca, 2001). These results suggest that OEA may contribute to the peripheral regulation of feeding. In the present study, we have… CONTINUE READING
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