Modulation of Mdm2 expression and p53-induced apoptosis in immortalized human ovarian granulosa cells.

Abstract

The activity of the tumor suppressor gene p53 is implicated in arrest of the cell cycle and the induction of apoptosis. The mdm2 oncogene is transcriptionally activated by p53, and the protein products of this gene can down-modulate biochemical activities and biological effects of p53 in a cell context-dependent manner. We have established highly… (More)

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