Modulation of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) by interferon-gamma in a human salivary gland cell line.

@article{Wu1997ModulationOM,
  title={Modulation of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) by interferon-gamma in a human salivary gland cell line.},
  author={Ava J Wu and Robert M Lafrenie and C Park and Wandee Apinhasmit and Zhi Jian Chen and Henning Birkedal-Hansen and Kenneth M Yamada and William G Stetler-Stevenson and B J Baum},
  journal={Journal of cellular physiology},
  year={1997},
  volume={171 2},
  pages={117-24}
}
Gelatinases have been shown to be regulated by many cytokines and growth factors, and have been implicated in the pathogenesis of certain autoimmune diseases via tissue destruction. High levels of several cytokines, including IFN-gamma and TNF-alpha, have been demonstrated in the salivary gland microenvironment of patients with Sjogren's syndrome (SS). How these cytokines may be contributing to the pathogenesis of this disease is not well understood. We hypothesized that IFN-gamma with or… CONTINUE READING