Modulation of MAO activity by imidazoline and guanidine derivatives.

  title={Modulation of MAO activity by imidazoline and guanidine derivatives.},
  author={Walter Raasch and Hartwig Muhle and Peter Dominiak},
  journal={Annals of the New York Academy of Sciences},
I2-binding sites (I2-BS) are attributed to be a regulative site on monoamine oxidase (MAO). The in vivo and in vitro effects of various imidazoline and guanidine derivatives on MAO activity and on mitochondrial respiration were studied. Substances with high affinity for I2-BS (antazoline, idazoxan, and cirazoline: IC50 = 20.3, 33.8, and 43.4 microM) had a stronger inhibitory effect on MAO activity than did I1-ligands (efaroxan, rilmenidine, clonidine, and moxonidine: IC50 = 277, 801, 1,224, and… CONTINUE READING