Modulation of Lipid Metabolism by Deep-Sea Water in Cultured Human Liver (HepG2) Cells

  title={Modulation of Lipid Metabolism by Deep-Sea Water in Cultured Human Liver (HepG2) Cells},
  author={Shan He and Jiejie Hao and Weibing Peng and Peiju Qiu and Chunxia Li and Huashi Guan},
  journal={Marine Biotechnology},
It has been found that deep-sea water was associated with lower serum lipid in animal model studies. Herein, we investigated whether DSW exerted a hypolipidemic activity and further elucidated how DSW modulated lipid metabolism in HepG2 cells. Preliminary animal studies showed that DSW exhibited potency to decrease serum total cholesterol, triglycerides, and LDL cholesterol, and increase HDL cholesterol, and the hepatic lipid contents were also significantly lower in the DSW group. When DSW was… 
Combination Treatment of Deep Sea Water and Fucoidan Attenuates High Glucose-Induced Insulin-Resistance in HepG2 Hepatocytes
It is suggested that co-treatment with DSW and FPS had a greater improving effect than DSW or FPS alone on IR, and might attenuate IR by targeting Akt/GSK-3β and AMPK pathways.
Deep Sea Water-Dissolved Organic Matter Intake Improves Hyperlipidemia and Inhibits Thrombus Formation and Vascular Inflammation in High-Fat Diet Hamsters
The data suggest that DSW-DOM intake via antioxidant defense mechanisms confers protective effects against high-fat diet-enhanced, oxidative stress-mediated hyperlipidemia, and endothelial dysfunction evoked atherosclerosis by downregulating oxidative injury, lipogenesis, inflammation and apoptosis.
Stimulatory Effect of Balanced Deep-Sea Water Containing Chitosan Oligosaccharides on Glucose Uptake in C2C12 Myotubes
BDSW containing COS has a greater stimulatory effect on glucose uptake than BDSW or COS alone, and this effect is mediated by the stimulation of diverse signaling pathways via the activation of main signaling molecules related to GSV trafficking.
Metals of Deep Ocean Water Increase the Anti-Adipogenesis Effect of Monascus-Fermented Product via Modulating the Monascin and Ankaflavin Production
Various individual metals resulted in different effects on MS and AK productions as well as the anti-adipogenesis effect of RMD, but the specific metals contained in DOW may cause synergistic or comprehensive effects that increase the significantly positive influence.
Effect of Minerals on Intestinal IgA Production Using Deep Sea Water Drinks.
It is suggested that physical properties of deep sea water drinks could be determined by their sources, and iron showed positive correlations with the fecal IgA, thus tending to stimulate immune function, but the extent of this effect varied by drink.
Deep Sea Water Alleviates Tau Phosphorylation and Cognitive Impairment via PI3K/Akt/GSK-3β Pathway
Data elucidated that DSW could improve Tau hyperphosphorylation and cognitive impairment, which were closely related with the stimulation of Akt/GSK-3β signaling, and the neuroprotective effects of DSW should be contributed to the synergistic effects of major and trace elements in it.
Increasing anti-Aβ-induced neurotoxicity ability of Antrodia camphorata-fermented product with deep ocean water supplementary.
DOW could be used as a promising supplementary for the production of A. camphorata secondary metabolites with strong antioxidant activity to protect neuron cells from damage based on Aβ stimulation cytotoxicity.
Deep sea water improves exercise and inhibits oxidative stress in a physical fatigue mouse model.
DSW can improve the athletic ability and alleviate physical fatigue of ICR mice by enhancing the antioxidant capacity, and this effect is achieved by enhancingThe antioxidant capacity.
Potential Health Benefits of Deep Sea Water: A Review
The potential health benefits of DSW are reviewed by referring to the findings from previous researches, which show it has potential to become a good source for health.
Drinking Refined Deep-Sea Water Improves the Gut Ecosystem with Beneficial Effects on Intestinal Health in Humans: A Randomized Double-Blind Controlled Trial
Drinking RDSW improves the intestinal environment, increasing fecal SCFAs and urinary isoflavones, which leads to broad beneficial effects in human.


Inhibitory Effect of Deep-sea Water on Differentiation of 3T3-L1 Adipocytes
A potential role for deep-sea water as anti-obesity agents by inhibiting adipocyte differentiation mediated through the down-regulated expression of adipogenic transcription factors and adipocyte-specific proteins is suggested.
Pharmacological activity of deep-sea water: examination of hyperlipemia prevention and medical treatment effect.
From these results, it is clear that deep-sea water controls the increase of serum lipid values (T-Cho and LDL-Cho) of cholesterol-fed rabbits, and promotes the reduction of serum cholesterol hyperlipemia rabbits.
Hep G2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids.
  • N. Javitt
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1990
Hep G2, a liver cell line derived from a human hepatoblastoma that is free of known hepatotropic viral agents, has been found to express a wide variety of liver-specific metabolic functions. Among
Anti-obesity and Antidiabetic Effects of Deep Sea Water on ob/ob Mice
The results suggest that continuous intake of deep sea water can ameliorate obesity and diabetes and suggest that the antidiabetic and anti-obesity activities of DSW were mediated by modulating the expression of diabetes- and obesity-specific molecules.
Activation of AMP‐activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
Findings reinforce the idea that pharmacological activation of AMPK may provide, through signalling and metabolic and gene expression effects, a new strategy for the management of metabolic hepatic disorders linked to type 2 diabetes and obesity.
Reverse cholesterol transport--a review of the process and its clinical implications.
Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.
A new metabolic disorder presenting with hyperlipidemia caused by a homozygous deletion mutation in CYP7A1 is reported, which leads to a frameshift that results in loss of the active site and enzyme function.
AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives
The identification of AMPK targets in hepatic metabolism should be useful in developing treatments to reverse metabolic abnormalities of type 2 diabetes and the metabolic syndrome.
Comparison of Mechanism and Functional Effects of Magnesium and Statin Pharmaceuticals
Since Mg2+-ATP is the controlling factor for the rate-limiting enzyme in the cholesterol biosynthesis sequence that is targeted by the statin pharmaceutical drugs, comparison of the effects of Mg2+