Modulation of LMP1 protein expression by EBV-encoded microRNAs.

  title={Modulation of LMP1 protein expression by EBV-encoded microRNAs.},
  author={Angela Kwok Fung Lo and Ka Fai To and Kwok Wai Lo and Raymond Wai Ming Lung and Jan Wai Ying Hui and Gangling Liao and Stephen D. Hayward},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 41},
Epstein-Barr virus (EBV) was the first human virus found to encode microRNAs (miRNAs), but the function of these miRNAs has been obscure. Nasopharyngeal carcinoma (NPC) is associated with EBV infection, and the EBV-encoded LMP1 is believed to be a key factor in NPC development. However, detection of LMP1 protein in NPC is variable. Here, we report that EBV-encoded BART miRNAs target the 3' UTR of the LMP1 gene and negatively regulate LMP1 protein expression. These miRNAs also modulate LMP1… CONTINUE READING
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