Modulation of L-type calcium current by internal potassium in guinea pig ventricular myocytes.

@article{Linz1997ModulationOL,
  title={Modulation of L-type calcium current by internal potassium in guinea pig ventricular myocytes.},
  author={Klaus W. Linz and Richard J. Jr. Meyer},
  journal={Cardiovascular research},
  year={1997},
  volume={33 1},
  pages={
          110-22
        }
}
OBJECTIVES The early phase of myocardial ischemia is characterized by a considerable K+ efflux from cardiac myocytes, causing decreasing internal ([K+]i) and increasing external ([K+]o) K+ concentrations. The change in [K+]i and [K+]o is one of the factors thought to initiate the ischemia-induced changes in electrical activity. Nevertheless, little is known about the influence of [K+]i and [K+]o on the L-type calcium current. METHODS The whole-cell patch-clamp technique combined with an… CONTINUE READING
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