Modulation of L-type Ca2+ current by isoprenaline, carbachol and phorbol ester in cultured rat aortic vascular smooth muscle (A7r5) cells.

@article{Satoh1995ModulationOL,
  title={Modulation of L-type Ca2+ current by isoprenaline, carbachol and phorbol ester in cultured rat aortic vascular smooth muscle (A7r5) cells.},
  author={H. Satoh and N. Sperelakis},
  journal={General pharmacology},
  year={1995},
  volume={26 2},
  pages={
          369-79
        }
}
1. Effects of isoprenaline (ISO), carbachol and phorbol ester (a stimulator of protein kinase C) on L-type Ca2+ channels in single cultured rat aortic vascular smooth muscle (A7r5) cells were examined using whole-cell voltage clamp (at room temperature 22 degrees C). 2. With 20 mmol/l Ca2+ in the bath solution and 10 mmol/l EGTA in the pipette solution, a slow ICa (L-type) current was observed in the A7r5 cell line, which was blocked by nifedipine (2 mumol/l). 3. ISO (5 mumol/l) inhibited ICa… Expand
Modulation of Ca2+-activated K+ current by isoprenaline, carbachol, and phorbol ester in cultured (and fresh) rat aortic vascular smooth muscle cells
Abstract 1. 1. Effects of isoprenaline (ISO), carbachol, and phorbol ester on the outward K+ currents in single cultured (or fresh) rat aortic vascular smooth muscle (A7r5 and A-10) cells wereExpand
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