Modulation of Kv4 channels, key components of rat ventricular transient outward K+ current, by PKC.

@article{Nakamura1997ModulationOK,
  title={Modulation of Kv4 channels, key components of rat ventricular transient outward K+ current, by PKC.},
  author={T Yatsuka Nakamura and William A Coetzee and Eleazar Vega-Saenz de Miera and Michael Artman and Bernardo Rudy},
  journal={The American journal of physiology},
  year={1997},
  volume={273 4},
  pages={
          H1775-86
        }
}
Current evidence suggests that members of the Kv4 subfamily may encode native cardiac transient outward current (I(to)). Antisense hybrid-arrest with oligonucleotides targeted to Kv4 mRNAs specifically inhibited rat ventricular I(to), supporting this hypothesis. To determine whether protein kinase C (PKC) affects I(to) by an action on these molecular components, we compared the effects of PKC activation on Kv4.2 and Kv4.3 currents expressed in Xenopus oocytes and rat ventricular I(to). Phorbol… CONTINUE READING
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