Modulation of Kv channel alpha/beta subunit interactions.

  title={Modulation of Kv channel alpha/beta subunit interactions.},
  author={Jeffrey R. Martens and Yong Geun Kwak and Michael M. Tamkun},
  journal={Trends in cardiovascular medicine},
  volume={9 8},
Voltage-gated K(+) channels comprise the largest and most diverse class of ion channels. These channels establish the resting membrane potential and modulate the frequency and duration of action potentials in nerve and muscle, as well as being the targets of several antiarrhythmic drugs in the heart. The multiplicity of Kv channel function is further enhanced through modulation by accessory beta subunits, which confer rapid inactivation, alter current amplitudes, and promote cell surface… CONTINUE READING

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