Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine.

@article{Main2000ModulationOK,
  title={Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine.},
  author={Martin J. Main and Jennifer E Cryan and Jonathan R B Dupere and B Cox and Jeffrey J. Clare and Stephen A. Burbidge},
  journal={Molecular pharmacology},
  year={2000},
  volume={58 2},
  pages={253-62}
}
Retigabine is a novel anticonvulsant with an unknown mechanism of action. It has recently been reported that retigabine modulates a potassium channel current in nerve growth factor-differentiated PC12 cells (), however, to date the molecular correlate of this current has not been identified. In the present study we have examined the effects of retigabine on recombinant human KCNQ2 and KCNQ3 potassium channels, expressed either alone or in combination in Xenopus oocytes. Application of 10 microM… CONTINUE READING

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