Modulation of Intracellular Cyclic AMP Levels by Different Human Dopamine D4 Receptor Variants

  title={Modulation of Intracellular Cyclic AMP Levels by Different Human Dopamine D4 Receptor Variants},
  author={Vida Asghari and Suparna Sanyal and Saskia Buchwaldt and Andrew D. Paterson and Vera Jovanovic and Hubert H. M. Van Tol},
  journal={Journal of Neurochemistry},
Abstract: To investigate whether polymorphic forms of the human dopamine D4 receptor have different functional characteristics, we have stably expressed cDNAs of the D4.2, D4.4, and D4.7 isoforms in several cell lines. Chinese hamster ovary CHO‐K1 cell lines expressing D4 receptor variants displayed pharmacological profiles that were in close agreement with previous data from transiently expressed D4 receptors in COS‐7 cells. Dopamine stimulation of the D4 receptors resulted in a concentration… 

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