Modulation of Ins(2,4,5)P3-stimulated Ca2+ mobilization by ins(1,3,4, 5)P4: enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative Ins(1,3,4,5)P4 receptor.

@article{LOOMISHUSSELBEE1998ModulationOI,
  title={Modulation of Ins(2,4,5)P3-stimulated Ca2+ mobilization by ins(1,3,4, 5)P4: enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative Ins(1,3,4,5)P4 receptor.},
  author={Jeff W. LOOMIS-HUSSELBEE and Cherryl D. Walker and Joanna R Bottomley and Peter J. Cullen and Robin F. Irvine and Alan Dawson},
  journal={The Biochemical journal},
  year={1998},
  volume={331 ( Pt 3)},
  pages={947-52}
}
We have previously shown that addition of Ins(1,3,4,5)P4 to permeabilized L1210 cells increases the amount of Ca2+ mobilized by a submaximal concentration of Ins(2,4,5)P3, and we suggested that, in doing this, Ins(1,3,4,5)P4 is not working via an InsP3 receptor but indirectly via an InsP4 receptor [Loomis-Husselbee, Cullen, Dreikhausen, Irvine and Dawson… CONTINUE READING