Modulation of Immune Cell Functions by the E3 Ligase Cbl-b


Maintenance of immunological tolerance is a critical hallmark of the immune system. Several signaling checkpoints necessary to balance activating and inhibitory input to immune cells have been described so far, among which the E3 ligase Cbl-b appears to be a central player. Cbl-b is expressed in all leukocyte subsets and regulates several signaling pathways… (More)
DOI: 10.3389/fonc.2015.00058


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