Modulation of Human Valve Interstitial Cell Phenotype and Function Using a Fibroblast Growth Factor 2 Formulation

@inproceedings{Latif2015ModulationOH,
  title={Modulation of Human Valve Interstitial Cell Phenotype and Function Using a Fibroblast Growth Factor 2 Formulation},
  author={Najma Latif and Alfred Quillon and Padmini Sarathchandra and Ann McCormack and Alec Lozanoski and Magdi Habib Yacoub and Adrian H Chester and Maurizio Pesce},
  booktitle={PloS one},
  year={2015}
}
Valve interstitial cells (VICs) are fibroblastic in nature however in culture it is widely accepted that they differentiate into a myofibroblastic phenotype. This study assessed a fibroblast culture media formulation for its ability to maintain the phenotype and function of VICs as in the intact healthy valve. Normal human VICs were cultured separately in standard DMEM and in fibroblast media consisting of FGF2 (10 ng/ml), insulin (50 ng/ml) and 2% FCS for at least a week. Cell morphology… CONTINUE READING

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