Modulation of GST P1-1 activity by polymerization during apoptosis.


Glutathione S-transferases (GSTs, EC belong to a large family of functionally different enzymes that catalyze the S-conjugation of glutathione with a wide variety of electrophilic compounds including carcinogens and anticancer drugs. Drug resistance may result from reduction in apoptosis of neoplastic cells when exposed to antineoplastic drugs… (More)


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