Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine
@article{Schlichter2000ModulationOG, title={Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine}, author={Rémy Schlichter and Volodymyr K. Rybalchenko and Pierrick Poisbeau and Marc Verleye and Jean-marie Gillardin}, journal={Neuropharmacology}, year={2000}, volume={39}, pages={1523-1535} }
104 Citations
The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit
- BiologyNeuropharmacology
- 2003
Functional modulation of gamma-aminobutyric acidA receptors by etifoxine and allopregnanolone in rodents
- BiologyNeuroscience Letters
- 2001
The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain
- Biology, MedicinePharmacology Biochemistry and Behavior
- 2005
Effects of etifoxine on ligand binding to GABAA receptors in rodents
- Biology, ChemistryNeuroscience Research
- 2002
Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats
- Biology, MedicineBrain Research
- 2007
Involvement of the GABAA receptor α subunit in the mode of action of etifoxine.
- Biology, PsychologyPharmacological research
- 2019
Functional modulation of gamma-aminobutyric acidA receptors by etifoxine and allopregnanolone in rodents
- Biology
- 2001
It is suggested that etifoxine and allopregnanolone bind to distinct putative recognition sites at or near the chloride channel site, and may have an additive effect by enhancing GABAA inhibitory transmission.
The Non-Benzodiazepine Anxiolytic Drug Etifoxine Causes a Rapid, Receptor-Independent Stimulation of Neurosteroid Biosynthesis
- Biology, MedicinePloS one
- 2015
It is demonstrated that etifoxine stimulates neurosteroid production through a membrane receptor-independent mechanism, and the stimulatory effects of et ifoxine and the triakontatetraneuropeptide TTN were additive, indicating that these two compounds act through distinct mechanisms.
Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice
- Biology, PsychologyBehavioural Brain Research
- 2010
Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.
- Biology, MedicinePharmacology & therapeutics
- 2007
References
SHOWING 1-10 OF 58 REFERENCES
Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function.
- BiologyEndocrine reviews
- 1993
Because of their abundance in peripheral tissues and in order to distinguish them from the GABAA or central benzodiazepine receptors, this class of benzodi...
Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology
- BiologyNature
- 1989
The isolation of a cloned cDNA encoding a new GABAA receptor subunit, termed γ2, which shares approximately 40% sequence identity with α-and β-subunits and whose messenger RNA is prominently localized in neuronal subpopulations throughout the CNS.
Etifoxine: evaluation of its anticonvulsant profile in mice in comparison with sodium valproate, phenytoin and clobazam.
- MedicineArzneimittel-Forschung
- 1985
It is concluded that etifoxine has a marked anticonvulsive potential and may be beneficially used in epileptic disorders, especially of the grand mal type.
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine.
- Psychology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 1998
The normalization of CSF ALLO content in depressed patients appears to be sufficient to mediate the anxiolytic and antidysphoric actions of fluoxetine or fluvoxamine via its positive allosteric modulation of GABA type A receptors.
Effect of Zolpidem on Miniature IPSCs and Occupancy of Postsynaptic GABAA Receptors in Central Synapses
- BiologyThe Journal of Neuroscience
- 1999
The increase of mIPSC amplitude by zolpidem provides evidence that the GABAA receptors are not saturated during miniature synaptic transmission in the recorded cells, and a similar degree of receptor occupancy at room and physiological temperature is estimated.
Modulation of GABAA receptor‐mediated IPSCs by neuroactive steroids in a rat hypothalamo‐hypophyseal coculture model.
- BiologyThe Journal of physiology
- 1997
The results suggest that, under physiological conditions, allopregnanolone might be a potent modulator of GABAergic synaptic transmission, acting at both pre‐ and postsynaptic sites.
Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neurons.
- Biology, ChemistryJournal of neurophysiology
- 1998
Results show that neocortical pyramidal cells have a population of GABAA receptors sensitive to both zinc and zolpidem, which enhanced mIPSCs in a concentration-dependent manner.
Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit
- BiologyNature
- 1997
A new class of human GABAA receptor subunit (η) that can assemble with α- and β-subunits and confer an insensitivity to the potentiating effects of intravenous anaesthetic agents is described.
δ Subunit Inhibits Neurosteroid Modulation of GABAAReceptors
- Biology, ChemistryThe Journal of Neuroscience
- 1996
The results suggest that developmental expression of GABAAreceptor δ subunits may play an important role in determining the region-specific neurosteroid-induced modification of fast inhibitory synaptic function.