Modulation of GABAergic Transmission by Activity via Postsynaptic Ca2+-Dependent Regulation of KCC2 Function

@article{Fiumelli2005ModulationOG,
  title={Modulation of GABAergic Transmission by Activity via Postsynaptic Ca2+-Dependent Regulation of KCC2 Function},
  author={Hubert Fiumelli and Laura Cancedda and Mu-Ming Poo},
  journal={Neuron},
  year={2005},
  volume={48},
  pages={773-786}
}
Activity-induced modification of GABAergic transmission contributes to the plasticity of neural circuits. In the present work we found that prolonged postsynaptic spiking of hippocampal neurons led to a shift in the reversal potential of GABA-induced Cl- currents (E(Cl)) toward positive levels in a duration- and frequency-dependent manner. This effect was abolished by blocking cytosolic Ca2+ elevation and mimicked by releasing Ca2+ from internal stores. Activity- and Ca2+-induced E(Cl) shifts… CONTINUE READING
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