Modulation of GABAA receptor function by alcohols: effects of subunit composition and differential effects of ethanol.

@article{Whitten1996ModulationOG,
  title={Modulation of GABAA receptor function by alcohols: effects of subunit composition and differential effects of ethanol.},
  author={R. J. Whitten and R. Maitra and J. Reynolds},
  journal={Alcoholism, clinical and experimental research},
  year={1996},
  volume={20 7},
  pages={
          1313-9
        }
}
We sought to test the hypotheses that closely related alcohols would have effects on GABAA receptor function that were not predicted by differences in lipid solubility, and that the subunit structure of the GABAA receptor would significantly affect the actions of different alcohols. Cloned subunits of human GABAA receptors were expressed in Xenopus oocytes, and two-electrode voltage-clamp recording was used to quantify the membrane current response to GABA in the presence and absence of… Expand
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