Modulation of GABA-mediated inhibition in rat cerebellar slices by benzodiazepine receptor ligands.

  title={Modulation of GABA-mediated inhibition in rat cerebellar slices by benzodiazepine receptor ligands.},
  author={S. Hussain and Jeff Bagust and R A Ward and Colin R. Gardner and Robert J. Walker},
  journal={General pharmacology},
  volume={22 5},
10 Citations
GABAA Receptors of Cerebellar Granule Cells in Culture: Interaction with Benzodiazepines
It is shown how rat cerebellar granule cells in culture may be a useful model for studying new benzodiazepine site agonists based on the pharmacological separation of diazepam-sensitive α1 β2/3 γ2 receptors from those which are diazepAM-insensitive and contain the α6 subunit.


Benzodiazepine receptors: Cellular and behavioral characteristics
Cerebellar GABAA receptor selective for a behavioural alcohol antagonist
It is concluded that this α-subunit is part of a cerebellar receptor subtype, selective for Rol5-4513 (refs 17, 18), an antagonist of alcohol-induced motor incoordination and ataxia, and photoaffinity-labelled with benzodiazepines.
Specific antagonism of GABA‐mediated postsynaptic inhibition in cultured mammalian spinal cord neurons
The hypothesis that the convulsant activity of these agents comes in part from selective antagonism of GABA-mediated postsynaptic inhibition is supported.
Heterogeneity of benzodiazepine receptor interactions with gamma-aminobutyric acid and barbiturate receptor sites.
The results suggest that the heterogeneous subpopulations of [3H]diazepam binding sites defined by the interactions with bicuculline/GABA and barbiturate/pyrazolopyridine receptors cannot yet be correlated in any simple way with agonist/antagonist conformational states of the benzodiazepine receptor nor subpopulation defined by heterogeneous binding affinities for some ligands.
Benzodiazepines specifically modulate GABA-mediated postsynaptic inhibition in cultured mammalian neurones
The effect of DZ and CDZ on amino acid-mediated postsynaptic responses in cultured mammalian spinal cord neurones is studied and it is reported that the BDZ selectively modify GABA-mediatedPostsynaptic inhibition in a dose-dependent fashion, augmenting the response at low doses and antagonising the response in higher doses.