Modulation of GABA-mediated inhibition in rat cerebellar slices by benzodiazepine receptor ligands.

@article{Hussain1991ModulationOG,
  title={Modulation of GABA-mediated inhibition in rat cerebellar slices by benzodiazepine receptor ligands.},
  author={S. Hussain and J. Bagust and R. A. Ward and C. Gardner and R. Walker},
  journal={General pharmacology},
  year={1991},
  volume={22 5},
  pages={
          907-15
        }
}
1. Extracellular recordings were made from the Purkinje cell layer of rat cerebellar slices. Compounds were perfused over the slice and bipolar stimulating electrodes placed in the external layer of the slice close to the recording electrode. 2. Stimulus-evoked inhibition of Purkinje layer cell activity was sensitive to bicuculline methiodide and picrotoxin, suggesting it was gamma-aminobutyric acid (GABA) mediated. The benzodiazepine ligands RU 32007 and Ro 19-0528 reversibly increased the… Expand
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The rapidly expanding range of neuronal benzodiazepine receptor ligands

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