Modulation of GABA-A receptors of astrocytes and STC-1 cells by taurine structural analogs

@article{ReyesHaro2014ModulationOG,
  title={Modulation of GABA-A receptors of astrocytes and STC-1 cells by taurine structural analogs},
  author={Daniel Reyes-Haro and E. Cabrera-Ru{\'i}z and Argel Estrada-Mondrag{\'o}n and R. Miledi and A. Mart{\'i}nez-Torres},
  journal={Amino Acids},
  year={2014},
  volume={46},
  pages={2587-2593}
}
Taurine activates and modulates GABA receptors in vivo as well as those expressed in heterologous systems. This study aimed to determine whether the structural analogs of taurine: homotaurine and hypotaurine, have the ability to activate GABA-A receptors that include GABAρ subunits. The expression of GABA-A receptors containing GABAρ has been reported in the STC-1 cells and astrocytes. In both cell types, taurine, homo-, and hypotaurine gated with low efficiency a picrotoxin-sensitive GABA-A… Expand
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